With the many Progressive-led States pushing for codifying "sanctuary city" status, the subject of nullification comes back into play. But Progressives - just as with the nuclear option in the US Senate - had think long and hard about what they are about to execute.
A poignant editorial in The Oklahoman pointed out that these Progressive-led States are - ironically - taking the path of the Confederacy during the US Civil War. The very States they castigate as bigoted because of the false-narrative that the Civil War was exclusively about slavery and not at all about State Rights and sovereignty from the Federal Government.
More to the point is that nullification cuts both ways, just like the nuclear option Harry Reid let out of Pandora's Box; an act that has come back to bite Democrats and Progressives in the ass.
Should these Progressive-led States push and establish nullification rights - which I can't really say I am against, then each state would be able to utilize the same precedent to nullify any federal law they would vote act against. That means Obamacare, EPA regulation, federal labor laws, etc.
As Thomas Jefferson is quoted as saying: "Whensoever the general government assumes undelegated powers...a nullification of the act is the rightful remedy."